Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexmedetomidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 11/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 11/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 11/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 8/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 7/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.97 |
| ▸ | HTR7 | P34969 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexmedetomidine SCHEMBL31048740 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL29945090 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL28305816 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29363193 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL787407 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29546835 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL30282088 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL2202289 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29833189 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL23498050 | 0.97 | ADRA2A (0.94) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7227 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122029243-A | Antifouling coating composition and antifouling coating film | 日本油漆船舶涂料公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4735541-A1 | ANTIFOULING COMPOSITION | Jotun A/S (NO) | 2026-05-06 | — | — | EP | claimed |
| EP-4728012-A1 | APPLICATION OF A BIOCIDE-CONTAINING FOULING CONTROL COMPOSITION BY ELECTROSTATIC SPRAYING | PPG Coatings Europe B.V. (NL) | 2026-04-22 | — | — | EP | claimed |
| EP-3805327-B1 | ANTIFOULING PAINT COMPOSITION | MITSUBISHI CHEM CORP (JP) | 2026-04-15 | — | — | EP | claimed |
| EP-3671287-B1 | MEDETOMIDINE COMPOSITIONS HAVING IMPROVED ANTI-FOULING CHARACTERISTICS | PGS GEOPHYSICAL AS (NO) | 2026-03-18 | — | — | EP | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260062562-A1 | SYSTEM FOR PRODUCING SUPERHYDROPHOBIC RUBBER AND PLASTIC COMPOUNDS WITH ANTIFOULING PROPERTIES | BARNACLE BLOCKER LLC (US) | 2026-03-05 | — | — | US | claimed |
| US-12565590-B2 | Antifouling coating composition and antifouling coating film | NIPPON PAINT MARINE COATINGS CO., LTD. (JP) | 2026-03-03 | — | — | US | claimed |
| US-20260041092-A1 | Composition Protecting Wood Against Marine Woodborers | I-TECH AB (SE) | 2026-02-12 | — | — | US | claimed |
| US-12501899-B2 | Mite infestation treatment | VETO-PHARMA (FR) | 2025-12-23 | — | — | US | claimed |
| WO-1992014453-A1 | COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN | ARC 1, INC. (US) | 1992-09-03 | — | — | WO | claimed |
| US-5091402-A | Local epidural or intraspinal administration for analgesia without sedation | ORION-YHTYMA OY (FI) | 1992-02-25 | — | — | US | claimed |
| EP-0300652-B1 | OPTICAL ISOMER OF AN IMIDAZOLE DERIVATIVE | ORION-YHTYMÀ OY (FI) | 1992-01-22 | — | — | EP | claimed |
| EP-0424059-A1 | Use of sustituted imidazoles for the manufacture of an analgesic | ORION-YHTYMÀ OY (FI) | 1991-04-24 | — | — | EP | claimed |
| WO-1991002505-A1 | METHOD AND DEVICE FOR ADMINISTERING DEXMEDETOMIDINE TRANSDERMALLY | CYGNUS RESEARCH CORPORATION (US) | 1991-03-07 | — | — | WO | claimed |
| US-4910214-A | Sedative, analgesics | FARMOS YHTYMA OY (FI) | 1990-03-20 | — | — | US | claimed |
| EP-0300652-A1 | Optical isomer of an imidazole derivative | ORION-YHTYMÀ OY (FI) | 1989-01-25 | — | — | EP | claimed |
| CN-1030576-A | Separation of optical isomers of imidazole from racemic modification | FARMOS OY (FI) | 1989-01-25 | — | — | CN | claimed |
| US-4783477-A | MEDETOMIDINE | FARMOS-YHTYMA OY (FI) | 1988-11-08 | — | — | US | claimed |
| EP-0270267-A2 | Anxiolytic composition | ORION-YHTYMÀ OY (FI) | 1988-06-08 | — | — | EP | claimed |