Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Medetomidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 11/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 11/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 11/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 8/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 7/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.97 |
| ▸ | HTR7 | P34969 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexmedetomidine SCHEMBL31048740 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL29945090 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL28305816 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29363193 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29546835 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL26433 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL30282088 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL2202289 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29833189 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL23498050 | 0.97 | ADRA2A (0.94) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 358 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12378421-B2 | Freeze-dried loaded aerogel particles with biocidal properties | AEROGEL APS (DK) | 2025-08-05 | — | — | US | claimed |
| EP-4363508-B1 | FREEZE-DRIED LOADED AEROGEL PARTICLES WITH BIOCIDAL PROPERTIES | AEROGEL APS (DK) | 2025-07-23 | — | — | EP | claimed |
| US-20240270982-A1 | FREEZE-DRIED LOADED AEROGEL PARTICLES WITH BIOCIDAL PROPERTIES | AEROGEL APS (DK) | 2024-08-15 | — | — | US | claimed |
| US-20230383129-A1 | ANTIFOULING COMPOUNDS | I-TECH AB (SE) | 2023-11-30 | — | — | US | claimed |
| WO-2023275311-A1 | PROCESS FOR FREEZE-DRIED LOADED AEROGEL PARTICLES WITH BIOCIDALPROPERTIES | AEROGEL APS (DK) | 2023-01-05 | — | — | WO | claimed |
| US-9290669-B2 | Waterborne antifouling coating composition | AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) | 2016-03-22 | — | — | US | claimed |
| EP-2785804-B1 | WATERBORNE ANTIFOULING COATING COMPOSITION | AKZO NOBEL COATINGS INT BV (NL) | 2015-11-18 | — | — | EP | claimed |
| US-20140318433-A1 | WATERBORNE ANTIFOULING COATING COMPOSITION | AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) | 2014-10-30 | — | — | US | claimed |
| EP-2785804-A2 | WATERBORNE ANTIFOULING COATING COMPOSITION | Akzo Nobel Coatings International BV (NL) | 2014-10-08 | — | — | EP | claimed |
| WO-2012150360-A2 | WATERBORNE ANTIFOULING COATING COMPOSITION | AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) | 2012-11-08 | — | — | WO | claimed |
| EP-2079706-B1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS | GRINDEKS JSC (LV) | 2011-07-20 | — | — | EP | claimed |
| US-20250375423-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-[1-(2,3-DIMETHYLPHENYL)ETHYL]-3H-IMIDAZOLE DERIVATIVES FOR TREATING RETINAL DISEASES | ALLERGAN INC (US) | 2025-12-11 | — | — | US | disclosed |
| US-20250325521-A1 | USE OF SUBLINGUAL DEXMEDETOMIDINE FOR THE TREATMENT OF AGITATION | BIOXCEL THERAPEUTICS INC (US) | 2025-10-23 | — | — | US | disclosed |
| US-12378421-B2 | Freeze-dried loaded aerogel particles with biocidal properties | AEROGEL APS (DK) | 2025-08-05 | — | — | US | disclosed |
| EP-4363508-B1 | FREEZE-DRIED LOADED AEROGEL PARTICLES WITH BIOCIDAL PROPERTIES | AEROGEL APS (DK) | 2025-07-23 | — | — | EP | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |
| US-20060223906-A1 | Method and use of acidified modified polymers to bind biocides in paints | I-TECH AB (SE) | 2006-10-05 | — | — | US | disclosed |
| WO-2006096128-A1 | METHOD AND USE OF NANOPARTICLES TO BIND BIOCIDES IN PAINTS | I-TECH (SE) | 2006-09-14 | — | — | WO | disclosed |
| WO-2006096129-A1 | METHOD AND USE OF ACIDIFIED MODIFIED POLYMERS TO BIND BIOCIDES IN PAINTS | I-TECH (SE) | 2006-09-14 | — | — | WO | disclosed |
| US-20060201379-A1 | Method and use of nanoparticles to bind biocides in paints | I-TECH AB (SE) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250375423-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-[1-(2,3-DIMETHYLPHENYL)ETHYL]-3H-IMIDAZOLE DERIVATIVES FOR TREATING RETINAL DISEASES | ALDH1A2, PDE6D, NR2E3 | ADRA2A 445/4885ADRA2B 255/4885ADRA2C 308/4885 |
| US-12378421-B2 | Freeze-dried loaded aerogel particles with biocidal properties | LCT, SOST, LBR | ADRA2A 2103/4885ADRA2B 2803/4885ADRA2C 3582/4885 |
| US-20240270982-A1 | FREEZE-DRIED LOADED AEROGEL PARTICLES WITH BIOCIDAL PROPERTIES | LCT, SOST, LBR | ADRA2A 2103/4885ADRA2B 2803/4885ADRA2C 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.