Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexmedetomidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 11/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 11/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 11/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 8/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 7/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.97 |
| ▸ | HTR7 | P34969 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexmedetomidine SCHEMBL31048740 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL29945090 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL28305816 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL787407 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29546835 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL26433 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL30282088 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Medetomidine SCHEMBL2202289 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL29833189 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Dexmedetomidine SCHEMBL23498050 | 0.97 | ADRA2A (0.94) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399247-A1 | ACRYLATE COATING COMPOSITION FOR FORMING AN ANTIFOULING COAT | Hempel A/S (DK) | 2024-07-17 | — | — | EP | disclosed |
| CN-115023136-B | Use of biocidal aerogel compositions in onshore paints, coatings and sealants | 气凝胶有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-115023137-B | Use of biocidal aerogel compositions in marine paints and coatings | 气凝胶有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-115038332-B | Biocidal aerogel compositions for surface protection | 气凝胶有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-117730125-A | Freeze-dried loaded aerogel particles with biocidal properties | 气凝胶有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-112352024-B | Encapsulated biocides and biostimulants | 气凝胶有限公司 | 2023-11-03 | — | — | CN | disclosed |
| WO-2023139212-A1 | CURABLE POLYSILOXANE COATING COMPOSITION COMPRISING POLYSILAZANE | DANMARKS TEKNISKE UNIVERSITET (DK) | 2023-07-27 | — | — | WO | disclosed |
| WO-2023036923-A1 | ACRYLATE COATING COMPOSITION FOR FORMING AN ANTIFOULING COAT | HEMPEL A/S (DK) | 2023-03-16 | — | — | WO | disclosed |
| CN-114015267-B | Encapsulated biocides and biological repellents | 气凝胶有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-115038332-A | Biocidal aerogel compositions for surface protection | 气凝胶有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115023136-A | Use of biocidal aerogel compositions in on-shore paints, coatings and sealants | 气凝胶有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-115023137-A | Use of biocidal aerogel compositions in marine paints and coatings | 气凝胶有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-110117464-B | Novel polysiloxane-based fouling control coating systems | 汉伯公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-110431195-B | Antifouling composition | 佐敦有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-114015267-A | Encapsulated biocides and biological repellents | 气凝胶有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-110139903-B | Antifouling coating composition comprising novel carbon-based hydrolysable polymers | 汉伯公司 | 2022-01-28 | — | — | CN | disclosed |