Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 9/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.46 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26435896 | 0.92 | IL1B (0.58) | IL1BNLRP3TNFCHEK2ROCK2 | |
| SCHEMBL26435361 | 0.89 | NLRP3 (0.46) | IL1BNLRP3TNFCHEK2ROCK2 | |
| SCHEMBL26437127 | 0.87 | IL1B (0.45) | IL1BNLRP3TNFROCK2KAT2B | |
| SCHEMBL30624984 | 0.86 | IL1B (0.63) | IL1BNLRP3TNFCHEK2KDM4E | |
| SCHEMBL26435305 | 0.86 | IL1B (0.63) | IL1BNLRP3TNFCHEK2KDM4E | |
| SCHEMBL26435667 | 0.86 | IL1B (0.48) | IL1BNLRP3TNFKAT2BKDM4E | |
| SCHEMBL26435878 | 0.85 | IL1B (0.44) | IL1BNLRP3 | |
| SCHEMBL24574849 | 0.85 | NLRP3 (0.65) | IL1BNLRP3TNFCHEK2KDM4E | |
| SCHEMBL30375097 | 0.85 | NLRP3 (0.65) | IL1BNLRP3TNFCHEK2KDM4E | |
| SCHEMBL25854629 | 0.85 | NLRP3 (0.44) | IL1BNLRP3TNFKAT2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116969920-A | Fused pyridazine derivative, preparation method and medical application thereof | 上海辉启生物医药科技有限公司 | 2023-10-31 | — | — | CN | disclosed |
| WO-2023066377-A1 | NITROGEN-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 索智生物科技（浙江）有限公司 | 2023-04-27 | — | — | WO | disclosed |