SCHEMBL26437270 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	NLRP3	Q96P20	2/20	0.42

▸	KCNH2	Q12809	1/20	0.41

▸	CNR1	P21554	1/20	0.38

▸	SYK	P43405	1/20	0.36

▸	IDH1	O75874	2/20	0.34

▸	TNF	P01375	1/20	0.34

▸	IL1B	P01584	1/20	0.34

▸	MAPK8	P45983	1/20	0.33

▸	HTR1A	P08908	2/20	0.33

▸	IRAK1	P51617	1/20	0.32

▸	HSD11B1	P28845	1/20	0.32

▸	OPRK1	P41145	2/20	0.31

▸	MKNK1	Q9BUB5	1/20	0.31

▸	MKNK2	Q9HBH9	1/20	0.31

▸	IRAK4	Q9NWZ3	3/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL26437253	0.89	NLRP3 (0.39)	NLRP3KCNH2CNR1SYKIDH1
SCHEMBL26437242	0.86	NLRP3 (0.53)	NLRP3KCNH2IDH1TNFIL1B
SCHEMBL26092528	0.86	NLRP3 (0.53)	NLRP3KCNH2IDH1TNFIL1B
SCHEMBL30375457	0.86	NLRP3 (0.53)	NLRP3KCNH2IDH1TNFIL1B
SCHEMBL29326482	0.83	NLRP3 (0.51)	NLRP3KCNH2CNR1IDH1TNF
SCHEMBL26434277	0.83	NLRP3 (0.51)	NLRP3KCNH2CNR1IDH1TNF
SCHEMBL26434265	0.82	IL1B (0.42)	NLRP3KCNH2CNR1SYKIDH1
SCHEMBL26437600	0.81	NLRP3 (0.57)	NLRP3KCNH2CNR1SYKTNF
SCHEMBL26437415	0.81	IL1B (0.43)	NLRP3KCNH2CNR1SYKTNF
SCHEMBL26089652	0.81	IL1B (0.43)	NLRP3KCNH2CNR1SYKTNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023066377-A1	NITROGEN-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF	索智生物科技（浙江）有限公司	2023-04-27	—	—	WO	disclosed