Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM2 | O94759 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20756450 | 0.89 | TRPM2 (0.41) | TRPM2LMNAPOLBTSHRNPSR1 | |
| SCHEMBL14555812 | 0.80 | TRPM2 (0.44) | TRPM2LMNAPOLBTSHRNPSR1 | |
| SCHEMBL15724335 | 0.78 | TRPM2 (0.47) | TRPM2LMNAPOLBTSHRNPSR1 | |
| SCHEMBL21420050 | 0.77 | POLB (0.38) | TRPM2POLBTSHRCYP2C19CYP2C9 | |
| SCHEMBL21420046 | 0.77 | POLB (0.40) | TRPM2POLBTSHRCYP2C19CYP2C9 | |
| SCHEMBL21420079 | 0.77 | POLB (0.38) | TRPM2POLBTSHRCYP2C19CYP2C9 | |
| SCHEMBL14487702 | 0.77 | POLB (0.40) | TRPM2POLBTSHRCYP2C19CYP2C9 | |
| SCHEMBL26251001 | 0.77 | POLB (0.40) | TRPM2POLBTSHRCYP2C19CYP2C9 | |
| SCHEMBL26437685 | 0.76 | TRPM2 (0.39) | TRPM2LMNAPOLBTSHRNPSR1 | |
| SCHEMBL14487805 | 0.75 | TRPM2 (0.47) | TRPM2LMNAPOLBTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4253366-A2 | METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION | Gilead Sciences, Inc. (US) | 2023-10-04 | — | — | EP | disclosed |