Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30407862 | 1.00 | GRM5 (0.37) | GRM5MCL1BAK1CTSLCTSB | |
| SCHEMBL26087316 | 0.87 | GRM5 (0.37) | GRM5MCL1BAK1CTSLCTSB | |
| SCHEMBL26089193 | 0.84 | CNR1 (0.38) | GRM5MCL1BAK1NAAAHRH4 | |
| SCHEMBL26087526 | 0.81 | LMNA (0.34) | GRM5CTSLCTSBCTSKNAAA | |
| SCHEMBL26089894 | 0.77 | MCL1 (0.40) | GRM5MCL1BAK1 | |
| SCHEMBL30407808 | 0.77 | MCL1 (0.40) | GRM5MCL1BAK1CNR1 | |
| SCHEMBL30694252 | 0.73 | GRM5 (0.38) | GRM5CTSLCTSBCTSKNAAA | |
| SCHEMBL31111706 | 0.69 | HRH4 (0.37) | GRM5HRH4 | |
| SCHEMBL26088997 | 0.67 | FEN1 (0.42) | GRM5MCL1BAK1CNR1 | |
| SCHEMBL19586153 | 0.67 | L3MBTL1 (0.48) | GRM5MCL1BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069708-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND USES THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |