Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 17/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | TACR2 | P21452 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264433 | 1.00 | TACR1 (1.00) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7020109 | 1.00 | TACR1 (1.00) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7023200 | 1.00 | TACR1 (1.00) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7024355 | 0.91 | TACR1 (0.83) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7906246 | 0.89 | TACR1 (0.81) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7019985 | 0.89 | TACR1 (0.81) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7506741 | 0.89 | TACR1 (0.81) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4440026 | 0.89 | TACR1 (0.81) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9084405 | 0.88 | TACR1 (0.79) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9035451 | 0.88 | TACR1 (0.79) | TACR1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020002164-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO., INC. | 2002-01-03 | — | — | US | claimed |
| US-6048859-A | ANTIEMETIC AGENT | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | claimed |
| EP-0577394-B1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO INC (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1995023798-A1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-09-08 | — | — | WO | claimed |
| WO-1994000440-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | claimed |
| EP-0577394-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | claimed |
| JP-6172178-A | — | — | None | — | — | JP | disclosed |
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-20110094321-A1 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-04-28 | — | — | US | disclosed |
| EP-1942734-A2 | PREPARATION OF APREPITANT | Dr. Reddy's Laboratories Ltd. (IN) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007044829-A2 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-04-19 | — | — | WO | disclosed |
| US-6638930-B2 | Antiinflammatory agents, analgesics, antiasthmatics, antiemitics and calcium channel blockers for angina, hypertension or ischemia | MERCK & CO. INC. | 2003-10-28 | — | — | US | disclosed |
| EP-0748320-B1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| US-5512570-A | Treatment of emesis with morpholine tachykinin receptor antagonists | MERCK & CO., INC. (US) | 1996-04-30 | — | — | US | disclosed |
| US-5457107-A | For treating inflammatory diseases, pain or migraine, asthma and emesis | MERCK & CO., INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995023798-A1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-09-08 | — | — | WO | disclosed |
| WO-1995016679-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-06-22 | — | — | WO | disclosed |
| JP-H06172178-A | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONIST | MERCK & CO INC | 1994-06-21 | — | — | JP | disclosed |
| WO-1994000440-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0577394-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002164-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | TRPM7, TRPM2, TRPM5 | TACR1 23/4885TP53 4582/4885CYP1A2 1179/4885 |
| US-20110094321-A1 | PREPARATION OF APREPITANT | KIT, CPA3, CMA1 | TACR1 5/4885TP53 3402/4885CYP1A2 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.