Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16252851 | 0.89 | NCF1 (0.52) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL8060951 | 0.85 | NCF1 (0.48) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL803131 | 0.84 | NCF1 (0.50) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL7356796 | 0.81 | NCF1 (0.47) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL11904335 | 0.81 | NCF1 (0.47) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL26294685 | 0.81 | NCF1 (0.47) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL19053405 | 0.79 | LOXL2 (0.47) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL7348696 | 0.79 | NCF1 (0.46) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL14692676 | 0.79 | LOXL2 (0.44) | NCF1LOXL2SSTR4HTR1AADRA1D | |
| SCHEMBL29393436 | 0.78 | NCF1 (0.44) | NCF1LOXL2SSTR4HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134004-B2 | Substituted N-bicyclicalkyl bicycliccarboxyamide compounds | PFIZER INC. (US) | 2012-03-13 | — | — | US | disclosed |