Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26457407 | 0.72 | NPC1 (0.44) | CYP3A4KDM4ENPC1RAB9AMAPT | |
| SCHEMBL1224754 | 0.71 | ALDH1A1 (0.56) | TRPM5ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL27794596 | 0.71 | ALDH1A1 (0.56) | TRPM5ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL27917394 | 0.68 | ALDH1A1 (0.45) | TRPM5ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL899929 | 0.68 | ALDH1A1 (0.45) | TRPM5ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL902793 | 0.66 | ALDH1A1 (0.43) | ALDH1A1CYP3A4KDM4ENPC1RAB9A | |
| SCHEMBL10025840 | 0.65 | CHRNB4 (0.42) | ALDH1A1CCNE1CDK2CDK5KDM4E | |
| SCHEMBL5570154 | 0.65 | PIM1 (0.40) | TRPM5ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL29027447 | 0.64 | ALDH1A1 (0.41) | TRPM5ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL30099834 | 0.61 | ALDH1A1 (0.67) | ALDH1A1CYP3A4KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072969-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |
| EP-4173674-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | disclosed |