Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CHRNG | P07510 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CHRND | Q07001 | 1/20 | 0.42 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960851 | 0.82 | CHRNB2 (0.67) | CHRNB4CHRNA3CHRNA1ESR1CHRNG | |
| SCHEMBL2616761 | 0.80 | CHRNB2 (0.62) | CHRNB4CHRNA3CHRNA1ESR1CHRNG | |
| SCHEMBL13561408 | 0.80 | CHRNB2 (0.62) | CHRNB4CHRNA3CHRNA1ESR1CHRNG | |
| SCHEMBL16582868 | 0.74 | LMNA (0.45) | CCNE1CDK2CDK5HTTMEN1 | |
| SCHEMBL17672031 | 0.71 | BACE1 (0.55) | CHRNA7NPC1POLBRAB9ACCNE1 | |
| SCHEMBL22288192 | 0.71 | ALDH1A1 (0.49) | CHRNA7ALDH1A1CASP1HTTMEN1 | |
| SCHEMBL150476 | 0.71 | NPC1 (0.65) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL29350099 | 0.71 | NPC1 (0.65) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL11460811 | 0.70 | BACE1 (0.58) | CHRNA7NPC1POLBRAB9ACCNE1 | |
| SCHEMBL4971125 | 0.70 | BACE1 (0.50) | CHRNA7ALDH1A1CASP1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178537-B2 | Solid state forms of varenicline salts and processes for preparation thereof | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-05-15 | — | — | US | disclosed |
| US-20100324055-A1 | SOLID STATES FORMS OF VARENICLINE SALTS AND PROCESSES FOR PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324055-A1 | SOLID STATES FORMS OF VARENICLINE SALTS AND PROCESSES FOR PREPARATION THEREOF | SPIN2B, CACNA1S, VARS1 | CHRNB4 155/4885CHRNA3 87/4885CHRNA1 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.