SCHEMBL26463103

SCHEMBL26463103

Cc1ccncc1-c1ccc2[nH]cnc2c1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 5/20 0.48
▸ CYP11B1 P15538 4/20 0.47
▸ CYP11B2 P19099 4/20 0.47
▸ DYRK1A Q13627 2/20 0.45
▸ CLK2 P49760 1/20 0.45
▸ CLK3 P49761 1/20 0.45
▸ QPCT Q16769 1/20 0.44
▸ QPCTL Q9NXS2 1/20 0.44
▸ WNT1 P04628 2/20 0.44
▸ PRKCI P41743 1/20 0.41
▸ TDO2 P48775 1/20 0.41
▸ PRMT5 O14744 1/20 0.41
▸ WDR77 Q9BQA1 1/20 0.41
▸ PTGS2 P35354 1/20 0.39
▸ NFATC1 O95644 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13373350 0.80 QPCT (0.51) QPCTQPCTL
SCHEMBL30494163 0.77 CLK2 (0.48) ABL1CYP11B1CYP11B2DYRK1ACLK2
SCHEMBL26463119 0.77 CLK2 (0.48) ABL1CYP11B1CYP11B2DYRK1ACLK2
SCHEMBL7021134 0.76 QPCT (0.49) CYP11B1CYP11B2DYRK1ACLK2QPCT
SCHEMBL6008269 0.75 MAPT (0.50) QPCTQPCTLPRKCI
SCHEMBL31143361 0.75 MAPT (0.50) QPCTQPCTLPRKCI
SCHEMBL26463099 0.75 CCNC (0.56) ABL1CYP11B1CYP11B2DYRK1ACLK2
SCHEMBL30494427 0.75 CCNC (0.56) ABL1CYP11B1CYP11B2DYRK1ACLK2
SCHEMBL30494494 0.74 ABL1 (0.52) ABL1CYP11B1CYP11B2DYRK1ACLK2
SCHEMBL26463431 0.74 ABL1 (0.52) ABL1CYP11B1CYP11B2DYRK1ACLK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250236613-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2025-07-24 — — US disclosed
EP-4423067-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2024-09-04 — — EP disclosed
CN-118176181-A SARM1 modulators, their preparation and use 维泰瑞隆有限公司 2024-06-11 — — CN disclosed
WO-2023072026-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-05-04 — — WO disclosed
WO-2023072026-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250236613-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SARM1, ADRM1, SMN1; SMN2 ABL1 4640/4885CYP11B1 4003/4885CYP11B2 4133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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