Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.48 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.48 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.48 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.48 |
| ▸ | TACR2 | P21452 | 3/20 | 0.47 |
| ▸ | GJB2 | P29033 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.44 |
| ▸ | CDC25B | P30305 | 6/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419923 | 0.89 | GJB2 (0.48) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL14750936 | 0.85 | HTR1A (0.42) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL22419916 | 0.83 | HTR1A (0.42) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL22419918 | 0.83 | HTR1A (0.42) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL10945729 | 0.82 | PTPN1 (0.52) | NT5ESSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL23744216 | 0.82 | HTR1A (0.52) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL20404663 | 0.82 | HTR1A (0.52) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL21283070 | 0.82 | HTR1A (0.52) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL20010200 | 0.82 | HTR1A (0.52) | HTR1ANT5ESSTR1SSTR2SSTR4 | |
| SCHEMBL18896703 | 0.82 | HTR1A (0.52) | HTR1ANT5ESSTR1SSTR2SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163703-B2 | Hepatitis C therapies | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8133870-B2 | Therapeutic furopyrimidines and thienopyrimidines | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20100143300-A1 | HEPATITIS C THERAPIES | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2010-06-10 | — | — | US | disclosed |
| US-7514410-B2 | Hepatitis C therapies | BIOCRYST PHARMACEUTICALS, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20080300200-A1 | Therapeutic Furopyrimidines and Thienopyrimidines | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| US-7429571-B2 | Therapeutic furopyrimidines and thienopyrimidines | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300200-A1 | Therapeutic Furopyrimidines and Thienopyrimidines | DPYD, TYMP, TYMS | HTR1A 4285/4885NT5E 170/4885SSTR1 4452/4885 |
| US-20100143300-A1 | HEPATITIS C THERAPIES | HAVCR2, FABP1, LIPC | HTR1A 4620/4885NT5E 1126/4885SSTR1 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.