SCHEMBL26464151

SCHEMBL26464151

CC(C)(C)OC(=O)NCCCOc1c(-c2csc(N3CCOCC3)n2)ccc(F)c1F

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 13/20 0.61
▸ VHL P40337 1/20 0.46
▸ RAF1 P04049 1/20 0.41
▸ BRAF P15056 1/20 0.41
▸ BRD4 O60885 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ LMNA P02545 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ NR2F2 P24468 1/20 0.38
▸ PIK3CG P48736 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30219486 1.00 AR (0.61) ARVHLRAF1BRAFBRD4
SCHEMBL30617816 0.93 AR (0.59) ARVHLRAF1BRAFNPC1
SCHEMBL25942618 0.93 AR (0.59) ARVHLRAF1BRAFNPC1
SCHEMBL30219491 0.93 AR (0.59) ARVHLRAF1BRAFNPC1
SCHEMBL30291247 0.93 AR (0.59) ARVHLRAF1BRAFNPC1
SCHEMBL30291248 0.93 AR (0.59) ARVHLRAF1BRAFNPC1
SCHEMBL28650197 0.92 AR (0.58) ARVHLRAF1BRAFBRD4
SCHEMBL30617809 0.92 AR (0.57) ARVHLRAF1BRAFBRD4
SCHEMBL30908029 0.92 AR (0.57) ARVHLRAF1BRAFBRD4
SCHEMBL25942687 0.87 AR (0.60) ARVHLRAF1BRAFNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230132823-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2023-05-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230132823-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 AR 1/4885VHL 525/4885RAF1 2845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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