SCHEMBL26464308

SCHEMBL26464308

O=C(O)CCC(=O)NCCOCCOc1c(-c2csc(N3CCOCC3)n2)ccc(F)c1F

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 14/20 0.57
▸ VHL P40337 1/20 0.42
▸ LMNA P02545 2/20 0.39
▸ HTT P42858 1/20 0.39
▸ RAB9A P51151 5/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ NPC1 O15118 4/20 0.38
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ MAPK1 P28482 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30219489 1.00 AR (0.57) ARVHLLMNAHTTRAB9A
SCHEMBL26458194 0.93 AR (0.60) ARVHLLMNAHTTRAB9A
SCHEMBL22263276 0.91 AR (0.62) ARVHLLMNAHTTRAB9A
SCHEMBL28658355 0.91 AR (0.62) ARVHLLMNAHTTRAB9A
SCHEMBL22263314 0.91 AR (0.62) ARVHLLMNAHTTRAB9A
SCHEMBL26464414 0.90 AR (0.60) ARVHLLMNAHTTRAB9A
SCHEMBL23846243 0.85 AR (0.56) ARVHLLMNAHTTRAB9A
SCHEMBL30219491 0.85 AR (0.59) ARVHLLMNAHTTRAB9A
SCHEMBL30291248 0.85 AR (0.59) ARVHLLMNAHTTRAB9A
SCHEMBL30617816 0.85 AR (0.59) ARVHLLMNAHTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230132823-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR DBD THERAPEUTICS, LLC 2023-05-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230132823-A1 BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR AR, ADRM1, PSMA3 AR 1/4885VHL 525/4885LMNA 3241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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