Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465691 | 0.91 | HPGD (0.53) | HPGDCACNA1HHTTTSHRKDM4E | |
| SCHEMBL26464783 | 0.88 | CACNA1H (0.46) | HPGDCACNA1HHTTL3MBTL1KMT2A | |
| SCHEMBL26465810 | 0.87 | CACNA1H (0.47) | HPGDCACNA1HHTTKDM4EMAPT | |
| SCHEMBL26465812 | 0.87 | CACNA1H (0.47) | HPGDCACNA1HTSHRKDM4EKMT2A | |
| SCHEMBL26466245 | 0.87 | HTT (0.55) | HPGDCACNA1HHTTTSHRKDM4E | |
| SCHEMBL26466418 | 0.87 | HTT (0.55) | HPGDCACNA1HHTTTSHRKDM4E | |
| SCHEMBL26466230 | 0.87 | HTT (0.55) | HPGDCACNA1HHTTTSHRKDM4E | |
| SCHEMBL26465708 | 0.86 | CACNA1H (0.49) | CACNA1HHTTTSHRKDM4EL3MBTL1 | |
| SCHEMBL26464500 | 0.86 | CACNA1H (0.70) | CACNA1HHTTKMT2AMAPTMEN1 | |
| SCHEMBL26465838 | 0.85 | CACNA1H (0.55) | CACNA1HALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |