Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 5/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465699 | 0.87 | HPGD (0.55) | CACNA1HMAPTTP53LMNAALDH1A1 | |
| SCHEMBL26465812 | 0.86 | CACNA1H (0.47) | CACNA1HMAPTLMNAALDH1A1CYP3A4 | |
| SCHEMBL26465692 | 0.86 | CACNA1H (0.45) | CACNA1HALDH1A1HPGDKDM4EGLA | |
| SCHEMBL26465708 | 0.85 | CACNA1H (0.49) | CACNA1HMAPTALDH1A1HTTKDM4E | |
| SCHEMBL26465813 | 0.85 | MAPT (0.43) | CACNA1HARMAPTTP53LMNA | |
| SCHEMBL26465696 | 0.83 | CACNA1H (0.44) | CACNA1HALDH1A1HPGDKDM4EGLA | |
| SCHEMBL26464500 | 0.81 | CACNA1H (0.70) | CACNA1HMAPTHTTTDP1 | |
| SCHEMBL26465691 | 0.81 | HPGD (0.53) | CACNA1HMAPTTP53LMNAALDH1A1 | |
| SCHEMBL26465838 | 0.80 | CACNA1H (0.55) | CACNA1HALDH1A1CACNA1GCYP2D6 | |
| SCHEMBL26464503 | 0.80 | KCNT1 (0.49) | CACNA1HLMNAALDH1A1CACNA1GPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |