Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466767 | 0.83 | SIGMAR1 (0.45) | SIGMAR1CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL26465984 | 0.82 | CACNA1H (0.40) | SIGMAR1CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL26465992 | 0.79 | CACNA1H (0.49) | CACNA1H | |
| SCHEMBL26465994 | 0.76 | CACNA1H (0.54) | CACNA1HKMT2A | |
| SCHEMBL26465830 | 0.74 | CACNA1H (0.73) | CACNA1HKMT2A | |
| SCHEMBL26466000 | 0.74 | CACNA1H (0.58) | CACNA1HKMT2A | |
| SCHEMBL2605751 | 0.73 | HPGD (0.53) | KMT2ACYP3A4HPGDLMNA | |
| SCHEMBL26465838 | 0.71 | CACNA1H (0.55) | CACNA1H | |
| SCHEMBL26463801 | 0.71 | CACNA1H (0.71) | CACNA1HKMT2A | |
| SCHEMBL18743777 | 0.70 | CACNA1H (0.46) | CACNA1HKMT2AGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |