Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466009 | 0.90 | CACNA1H (0.49) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26465563 | 0.89 | CACNA1H (0.42) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26466903 | 0.89 | CACNA1H (0.50) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26466012 | 0.88 | CACNA1H (0.45) | CACNA1HALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL26465080 | 0.86 | CACNA1H (0.56) | CACNA1HLMNAMEN1KMT2ACXCR6 | |
| SCHEMBL26465573 | 0.85 | CACNA1H (0.72) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26465564 | 0.85 | CACNA1H (0.43) | CACNA1HALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL26465825 | 0.83 | ALDH1A1 (0.44) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26466001 | 0.80 | L3MBTL1 (0.48) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26466097 | 0.80 | CACNA1H (0.45) | CACNA1HLMNAALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |