Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 11/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466406 | 1.00 | CACNA1H (0.54) | CACNA1HLTA4HMEN1KMT2ACRHBP | |
| SCHEMBL26466222 | 1.00 | CACNA1H (0.54) | CACNA1HLTA4HMEN1KMT2ACRHBP | |
| SCHEMBL26466386 | 0.92 | CACNA1H (0.45) | CACNA1HLTA4HMEN1KMT2ACRHBP | |
| SCHEMBL26466770 | 0.89 | CACNA1H (0.42) | CACNA1HLTA4HMEN1KMT2ALMNA | |
| SCHEMBL26466617 | 0.89 | CACNA1H (0.67) | CACNA1HLTA4HMEN1KMT2AKDM4E | |
| SCHEMBL26466598 | 0.87 | CACNA1H (0.46) | CACNA1HLTA4HMEN1KMT2ACRHBP | |
| SCHEMBL26466207 | 0.87 | CACNA1H (0.46) | CACNA1HLTA4HMEN1KMT2ACRHBP | |
| SCHEMBL26499134 | 0.85 | CACNA1H (0.51) | CACNA1HMEN1KMT2AKDM4ELMNA | |
| SCHEMBL26466398 | 0.83 | CACNA1H (0.49) | CACNA1HLTA4HCACNA1GCACNA1IALDH1A1 | |
| SCHEMBL26466387 | 0.83 | CACNA1H (0.49) | CACNA1HLTA4HCACNA1GCACNA1IALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |