Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 3/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466598 | 1.00 | CACNA1H (0.46) | CACNA1HKCNJ5KCNJ3EPHX2LTA4H | |
| SCHEMBL26464502 | 0.87 | CACNA1H (0.50) | CACNA1HKCNJ5KCNJ3EPHX2KDM4E | |
| SCHEMBL26466237 | 0.87 | CACNA1H (0.54) | CACNA1HLTA4HKDM4EMEN1CRHBP | |
| SCHEMBL26466406 | 0.87 | CACNA1H (0.54) | CACNA1HLTA4HKDM4EMEN1CRHBP | |
| SCHEMBL26466222 | 0.87 | CACNA1H (0.54) | CACNA1HLTA4HKDM4EMEN1CRHBP | |
| SCHEMBL26466770 | 0.86 | CACNA1H (0.42) | CACNA1HKCNJ5KCNJ3LTA4HCCKBR | |
| SCHEMBL26466216 | 0.86 | CACNA1H (0.47) | CACNA1HLTA4HKDM4ECCKBRALDH1A1 | |
| SCHEMBL26466596 | 0.84 | CACNA1H (0.40) | CACNA1HEPHX2LTA4HKDM4EMEN1 | |
| SCHEMBL26466999 | 0.83 | CACNA1H (0.42) | CACNA1HLTA4HKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL26466402 | 0.82 | CACNA1H (0.65) | CACNA1HCCKBRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |