Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26464766 | 0.91 | LMNA (0.47) | CACNA1HLMNAALDH1A1KDM4ECYP2D6 | |
| SCHEMBL26083796 | 0.89 | CACNA1H (0.59) | CACNA1HLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26082655 | 0.88 | CACNA1H (0.49) | CACNA1HLMNAALDH1A1SMN1; SMN2CACNA1G | |
| SCHEMBL26498772 | 0.88 | CACNA1H (0.64) | CACNA1HLMNAALDH1A1KDM4ECYP2D6 | |
| SCHEMBL26466406 | 0.85 | CACNA1H (0.54) | CACNA1HLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL26466222 | 0.85 | CACNA1H (0.54) | CACNA1HLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL26466237 | 0.85 | CACNA1H (0.54) | CACNA1HLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL26498773 | 0.83 | CACNA1H (0.47) | CACNA1HLMNAALDH1A1KDM4ECYP2D6 | |
| SCHEMBL26498774 | 0.82 | ALDH1A1 (0.53) | CACNA1HLMNAALDH1A1KDM4ECYP2D6 | |
| SCHEMBL26498845 | 0.81 | CACNA1H (0.64) | CACNA1HLMNAALDH1A1KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192664-A2 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A DIAZASPIROHEPTANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |