⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184103 | 1.00 | — | — | |
| SCHEMBL148424 | 0.73 | — | — | |
| SCHEMBL2727302 | 0.70 | — | — | |
| SCHEMBL1579883 | 0.69 | CYP2C9 (0.55) | — | |
| SCHEMBL20176818 | 0.69 | RAB9A (0.52) | — | |
| SCHEMBL1579884 | 0.69 | CYP2C9 (0.55) | — | |
| SCHEMBL1579880 | 0.69 | CYP2C9 (0.55) | — | |
| SCHEMBL28272902 | 0.69 | — | — | |
| SCHEMBL10413780 | 0.69 | — | — | |
| SCHEMBL4594308 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163703-B2 | Hepatitis C therapies | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8133870-B2 | Therapeutic furopyrimidines and thienopyrimidines | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20100143300-A1 | HEPATITIS C THERAPIES | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2010-06-10 | — | — | US | disclosed |
| US-7514410-B2 | Hepatitis C therapies | BIOCRYST PHARMACEUTICALS, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20080300200-A1 | Therapeutic Furopyrimidines and Thienopyrimidines | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| EP-1606351-A4 | CYANINE DYE LABELLING REAGENTS WITH MESO-SUBSTITUTION | GE HEALTHCARE BIO SCIENCES (US) | 2008-10-08 | — | — | EP | disclosed |
| US-7429571-B2 | Therapeutic furopyrimidines and thienopyrimidines | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-02-14 | — | — | US | disclosed |
| EP-1606351-A2 | CYANINE DYE LABELLING REAGENTS WITH MESO-SUBSTITUTION | Amersham Biosciences Corp. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004085539-A2 | CYANINE DYE LABELLING REAGENTS WITH MESO-SUBSTITUTION | AMERSHAM BIOSCIENCES CORP (US) | 2004-10-07 | — | — | WO | disclosed |
| EP-0046856-A2 | Process for preparing 4-amino-2-mercapto-pyrimidines | HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) | 1982-03-10 | — | — | EP | disclosed |