Sugi Predict

Sugi Predict / Compounds / SCHEMBL1664008

SCHEMBL1664008

SCHEMBL1664008

O=Cc1ccc(C(=O)NCCO)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 3/20 0.53
▸ HPGD P15428 2/20 0.53
▸ HTT P42858 1/20 0.53
▸ MMP13 P45452 1/20 0.53
▸ EPHX2 P34913 1/20 0.53
▸ NR1H4 Q96RI1 1/20 0.53
▸ CA12 O43570 1/20 0.51
▸ CA1 P00915 1/20 0.51
▸ CA2 P00918 1/20 0.51
▸ CA9 Q16790 1/20 0.51
▸ CA14 Q9ULX7 1/20 0.51
▸ ALDH1A1 P00352 5/20 0.48
▸ KDM4E B2RXH2 2/20 0.46
▸ SPHK2 Q9NRA0 1/20 0.44
▸ SPHK1 Q9NYA1 1/20 0.44
▸ MCHR1 Q99705 1/20 0.43
▸ NEK1 Q96PY6 1/20 0.43
▸ HDAC4 P56524 1/20 0.43
▸ HDAC6 Q9UBN7 1/20 0.43
▸ MAPK1 P28482 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13349295 0.86 POLB (0.60) POLBEPHX2NR1H4ALDH1A1HDAC4
SCHEMBL620074 0.86 POLB (0.66) POLBHPGDHTTMMP13CA12
SCHEMBL14730974 0.84 EPHX2 (0.46) POLBHPGDHTTMMP13EPHX2
SCHEMBL10050998 0.84 KDM4E (0.57) EPHX2NR1H4ALDH1A1KDM4EMAPK1
SCHEMBL9625733 0.84 EPHX2 (0.51) POLBEPHX2NR1H4ALDH1A1MAPK1
SCHEMBL23146039 0.84 MMP13 (0.55) POLBHPGDHTTMMP13CA12
SCHEMBL19262987 0.84 TSHR (0.64) EPHX2NR1H4ALDH1A1KDM4ESPHK2
SCHEMBL19832508 0.84 POLB (0.51) POLBHPGDHTTMMP13CA12
SCHEMBL13063463 0.84 EPHX2 (0.51) POLBEPHX2NR1H4ALDH1A1HDAC4
SCHEMBL12641858 0.82 GAA (0.57) POLBHPGDEPHX2NR1H4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 — — US disclosed
US-9622991-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2017-04-18 — — US disclosed
US-9144557-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2015-09-29 — — US disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 — — US disclosed
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-09-10 — — US disclosed
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-08-28 — — US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
EP-2642994-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS Ligand Pharmaceuticals Incorporated (US) 2013-10-02 — — EP disclosed
EP-1802593-B1 POLYMER-FILLER COUPLING ADDITIVES BRIDGESTONE CORP (JP) 2013-04-24 — — EP disclosed
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2012-11-22 — — US disclosed
EP-2488486-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES Ligand Pharmaceuticals Inc. (US) 2012-08-22 — — EP disclosed
WO-2012068406-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2012-05-24 — — WO disclosed
WO-2011046954-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2011-04-21 — — WO disclosed
US-7691883-B2 Cinnamoyl compound and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-06 — — US disclosed
US-20070265228-A1 Cinnamoyl compound and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-11-15 — — US disclosed
EP-1802593-A2 POLYMER-FILLER COUPLING ADDITIVES Bridgestone Corporation (JP) 2007-07-04 — — EP disclosed
US-7186845-B2 Polymer-filler coupling additives BRIDGESTONE CORPORATION (JP) 2007-03-06 — — US disclosed
EP-1671961-A1 CINNAMOYL COMPOUND AND USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2006-06-21 — — EP disclosed
WO-2006045088-A2 POLYMER-FILLER COUPLING ADDITIVES BRIDGESTONE CORPORATION (JP) 2006-04-27 — — WO disclosed
US-20060084730-A1 Polymer-filler coupling additives BRIDGESTONE CORPORATION (JP) 2006-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS HGF, EPOR, MPL POLB 3018/4885HPGD 737/4885HTT 1692/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK POLB 2133/4885HPGD 3245/4885HTT 3171/4885
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF POLB 3224/4885HPGD 1328/4885HTT 864/4885
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF POLB 3224/4885HPGD 1328/4885HTT 864/4885
US-20060084730-A1 Polymer-filler coupling additives AAAS, RECQL, PHAX POLB 206/4885HPGD 1803/4885HTT 18/4885
US-20070265228-A1 Cinnamoyl compound and use of the same NPC1, CES2, CYP51A1 POLB 4812/4885HPGD 1703/4885HTT 4279/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.