SCHEMBL2646943

SCHEMBL2646943

Cc1ccc(CBr)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
TRPA1 O75762 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP3A4 P08684 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
LMNA P02545 2/20 0.40
POLB P06746 1/20 0.40
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
ACHE P22303 2/20 0.39
ALOX12 P18054 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
MCHR1 Q99705 1/20 0.38
HTT P42858 1/20 0.37
CYP2C19 P33261 1/20 0.37
IDO1 P14902 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.36
BCHE P06276 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30705746 0.87 TRPA1 (0.59) TSHRTRPA1ALDH1A1CYP3A4TDP1
Benzyl Bromide SCHEMBL1043932 0.85 TSHR (0.70) TSHRTRPA1ALDH1A1CYP3A4TDP1
SCHEMBL10986585 0.83 CYP2A6 (0.46) TSHRTRPA1ALDH1A1CYP3A4TDP1
P-Xylene SCHEMBL10884475 0.82 TDP1 (0.71) TSHRALDH1A1CYP3A4TDP1CES2
SCHEMBL10426400 0.82 ALDH1A1 (0.52) TSHRTRPA1ALDH1A1CYP3A4TDP1
SCHEMBL275339 0.82 ALDH1A1 (0.52) TSHRTRPA1ALDH1A1CYP3A4TDP1
SCHEMBL12889884 0.80 TDP1 (0.67) TSHRALDH1A1CYP3A4TDP1CES2
P-Xylene SCHEMBL11108935 0.80 TDP1 (0.67) TSHRALDH1A1CYP3A4TDP1CES2
P-Xylene SCHEMBL11109973 0.80 TDP1 (0.67) TSHRALDH1A1CYP3A4TDP1CES2
SCHEMBL49480 0.80 TDP1 (0.67) TSHRALDH1A1CYP3A4TDP1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0790974-B1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS BAYER AG (US) 2002-08-14 EP disclosed
US-6218431-B1 GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES BAYER CORPORATION 2001-04-17 US disclosed
US-6166082-A Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors BAYER CORPORATION (US) 2000-12-26 US disclosed
EP-0934274-A1 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS Bayer Corporation (US) 1999-08-11 EP disclosed
US-5789434-A ACID, ESTER OR AMIDE DERIVATIVES AS ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS AND REDUCTION OF CARTILAGE DETERIORATION BAYER CORPORATION (US) 1998-08-04 US disclosed
WO-1998004528-A2 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS BAYER CORPORATION (US) 1998-02-05 WO disclosed
EP-0790974-A1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS Bayer Corporation (US) 1997-08-27 EP disclosed
WO-1996015096-A1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS BAYER CORPORATION (US) 1996-05-23 WO disclosed