SCHEMBL26470320

SCHEMBL26470320

CCC(=O)N[C@H]1CCc2c(C)c(F)cc(NC(C)=O)c2C1=O

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 19/20 0.42
CYP11B1 P15538 17/20 0.42
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22200884 0.90 LMNA (0.41) CYP11B2CYP11B1KDM4ELMNAPOLB
SCHEMBL20783225 0.90 LMNA (0.41) CYP11B2CYP11B1KDM4ELMNAPOLB
SCHEMBL26470798 0.87 RECQL (0.35) CYP11B2CYP11B1KDM4ELMNAPOLB
SCHEMBL26470796 0.86 KDM4E (0.38) KDM4ELMNAPOLBMAPT
SCHEMBL26471057 0.85 KDM4E (0.34) KDM4ELMNAPOLBMAPT
SCHEMBL26470794 0.85 KDM4E (0.33) KDM4ELMNAPOLBMAPT
SCHEMBL26623065 0.81 HDAC1 (0.36) KDM4ELMNA
SCHEMBL26623089 0.80 HDAC1 (0.35) KDM4ELMNAMAPT
SCHEMBL30741798 0.80 HDAC1 (0.33)
SCHEMBL24728325 0.79 LMNA (0.42) CYP11B2CYP11B1KDM4ELMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023072143-A1 CAMPTOTHECIN DERIVATIVE INTERMEDIATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海弼领生物技术有限公司 2023-05-04 WO disclosed