SCHEMBL2647128

SCHEMBL2647128

CCOC(=O)c1c(C(C)C)nc(OC)c(C=O)c1-c1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GCGR P47871 9/20 0.51
SLC10A2 Q12908 1/20 0.48
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
GRM6 O15303 1/20 0.42
MEN1 O00255 2/20 0.41
MAPT P10636 2/20 0.41
KMT2A Q03164 2/20 0.41
GPR55 Q9Y2T6 1/20 0.41
ALDH1A1 P00352 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
THRB P10828 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HTT P42858 1/20 0.40
TRPM8 Q7Z2W7 1/20 0.39
PRKCZ Q05513 1/20 0.39
CACNB4 O00305 1/20 0.39
CACNA1A O00555 1/20 0.39
CACNA1G O43497 1/20 0.39
CACNG3 O60359 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2647789 0.89 GCGR (0.55) GCGRSLC10A2ALDH1A1L3MBTL1HTT
SCHEMBL2662902 0.87 GCGR (0.55) GCGRSLC10A2POLBGAAGRM6
SCHEMBL5102017 0.86 GCGR (0.49) GCGRSLC10A2POLBGAAGRM6
SCHEMBL9152067 0.85 GCGR (0.61) GCGRSLC10A2POLBGAAGRM6
SCHEMBL2648326 0.84 GCGR (0.66) GCGRSLC10A2POLBGAAGRM6
SCHEMBL9149631 0.83 GCGR (0.56) GCGRSLC10A2POLBGAAGRM6
SCHEMBL2648212 0.83 GCGR (0.62) GCGRSLC10A2POLBGAAGRM6
SCHEMBL8846752 0.82 GCGR (0.54) GCGRSLC10A2ALDH1A1L3MBTL1CACNB4
SCHEMBL2647842 0.81 SLC10A2 (0.41) GCGRSLC10A2POLBGAAMEN1
SCHEMBL2647839 0.81 SLC10A2 (0.41) GCGRSLC10A2POLBGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6218431-B1 GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES BAYER CORPORATION 2001-04-17 US disclosed
EP-0934274-A1 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS Bayer Corporation (US) 1999-08-11 EP disclosed
WO-1998004528-A2 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS BAYER CORPORATION (US) 1998-02-05 WO disclosed