Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.55 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9152067 | 0.89 | GCGR (0.61) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL2648326 | 0.88 | GCGR (0.66) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL2647128 | 0.87 | GCGR (0.51) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL9149631 | 0.87 | GCGR (0.56) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL2648212 | 0.87 | GCGR (0.62) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL9737768 | 0.82 | GCGR (0.64) | GCGRSLC10A2GAAPOLBMAPT | |
| SCHEMBL13482768 | 0.82 | GCGR (0.64) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL8178136 | 0.82 | GCGR (0.64) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL9152690 | 0.81 | GCGR (0.50) | GCGRSLC10A2GRM6GAAPOLB | |
| SCHEMBL7560766 | 0.81 | GCGR (0.65) | GCGRSLC10A2GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |