Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652116 | 0.88 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2642029 | 0.87 | FGFR1 (0.52) | FGFR1HTTSRCKDR | |
| SCHEMBL9077115 | 0.86 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2652344 | 0.85 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2653086 | 0.85 | PRMT6 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2653075 | 0.84 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2646283 | 0.82 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2656285 | 0.82 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2647150 | 0.82 | FGFR1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL13045092 | 0.81 | FGFR1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0616807-B1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH AS (DK) | 1998-07-08 | — | — | EP | disclosed |
| US-5554632-A | CENTRAL NERVOUS SYSTEM | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| US-5554630-A | TREATING ANXIETY, CONVULSIONS AND SLEEP DISORDERS IN LIVING ANIMALS BY MODULATION OF THE BENZODIAZEPINE RECEPTOR OF THE CENTRAL NERVOUS SYSTEM WITH 1-/3-HETEROCYCLYLPHENYL/-BENZIMIDAZOLES | NEUROSEARCH A/S (DK) | 1996-09-10 | — | — | US | disclosed |
| EP-0616807-A1 | Benzimidazole useful in the treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1994-09-28 | — | — | EP | disclosed |