SCHEMBL26475950

SCHEMBL26475950

O=C(CBr)c1cc(Br)c2occc2c1F

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.34
GSK3B P49841 3/20 0.32
HPGDS O60760 1/20 0.31
CFD P00746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21437428 0.83 GPR35 (0.38) PTPN1
SCHEMBL23218247 0.82 MAOB (0.37)
SCHEMBL26094749 0.79 KCNA3 (0.44)
SCHEMBL23219171 0.76 HTR2A (0.33)
SCHEMBL21437650 0.75 HTR2A (0.33)
SCHEMBL23218844 0.73 HTR2C (0.30)
SCHEMBL4992632 0.72 GYS1 (0.30)
SCHEMBL23218438 0.72 PTPN1 (0.31) PTPN1
SCHEMBL6305380 0.69 HTR2A (0.32)
SCHEMBL23218572 0.69 NPC1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118176187-A Condensed ring compound, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2024-06-11 CN disclosed
WO-2023066357-A1 FUSED CYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2023-04-27 WO disclosed