Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647782 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2655326 | 0.93 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1GAARAB9AMAPT | |
| SCHEMBL2647767 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2647765 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2647969 | 0.87 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2648362 | 0.86 | ALDH1A1 (0.39) | SMN1; SMN2NPC1GAAALDH1A1L3MBTL1 | |
| SCHEMBL2649466 | 0.86 | POLB (0.37) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2649468 | 0.86 | POLB (0.37) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2650700 | 0.86 | LMNA (0.36) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL2650697 | 0.86 | LMNA (0.36) | SMN1; SMN2NPC1GAARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582769-B2 | Dicycloalkyl urea glucokinase activators | NOVO NORDISK A/S (DK) | 2009-09-01 | — | — | US | disclosed |
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-05-07 | — | — | US | disclosed |
| EP-1904466-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006760-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | GCK, GCKR, UCK2 | SMN1; SMN2 4814/4885NPC1 2090/4885GAA 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.