Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304318 | 0.92 | CEL (0.33) | TSHR | |
| SCHEMBL346764 | 0.92 | TSHR (0.35) | TSHR | |
| SCHEMBL6238652 | 0.90 | KMT2A (0.36) | — | |
| SCHEMBL15751193 | 0.84 | ESR2 (0.36) | TSHR | |
| SCHEMBL15751190 | 0.84 | ESR2 (0.36) | TSHR | |
| SCHEMBL10759055 | 0.81 | TSHR (0.32) | TSHR | |
| SCHEMBL346876 | 0.81 | TSHR (0.32) | TSHR | |
| SCHEMBL561422 | 0.81 | TSHR (0.32) | TSHR | |
| SCHEMBL14620427 | 0.75 | CEL (0.33) | — | |
| SCHEMBL10679447 | 0.75 | KMT2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |
| EP-0915875-A2 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004559-A2 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |