Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648307 | 0.84 | GCGR (0.57) | GCGR | |
| SCHEMBL27350569 | 0.81 | GCGR (0.45) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL27311063 | 0.80 | GCGR (0.42) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL6953311 | 0.77 | GCGR (0.49) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL2647866 | 0.77 | GCGR (0.50) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL2647302 | 0.75 | GCGR (0.48) | GCGR | |
| SCHEMBL9875036 | 0.74 | GCGR (0.39) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL6963404 | 0.74 | GCGR (0.47) | GCGR | |
| SCHEMBL9743385 | 0.70 | TRPM8 (0.38) | GCGR | |
| SCHEMBL6747779 | 0.69 | GCGR (0.74) | GCGRESR1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |
| EP-0934274-A1 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | Bayer Corporation (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004528-A2 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | BAYER CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |