SCHEMBL9743385

SCHEMBL9743385

CCOC(=O)c1c(N(C)C)nc(C(C)C)c(C(O[SiH](C)C)C(C)(C)C)c1-c1ccc(F)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.38
GCGR P47871 9/20 0.38
ALDH1A1 P00352 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
MAPT P10636 1/20 0.36
GPR55 Q9Y2T6 1/20 0.36
CACNB4 O00305 2/20 0.36
CACNA1A O00555 2/20 0.36
CACNA1G O43497 2/20 0.36
CACNG3 O60359 2/20 0.36
CACNA1F O60840 2/20 0.36
CACNA1H O95180 2/20 0.36
ACHE P22303 2/20 0.36
CACNB3 P54284 2/20 0.36
CACNA2D1 P54289 2/20 0.36
CACNG7 P62955 2/20 0.36
CACNA1B Q00975 2/20 0.36
CACNA1D Q01668 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2647302 0.90 GCGR (0.48) TRPM8GCGRALDH1A1L3MBTL1MEN1
SCHEMBL9152685 0.83 GCGR (0.45) TRPM8GCGRALDH1A1L3MBTL1MEN1
SCHEMBL9269784 0.83 GCGR (0.41) TRPM8GCGRALDH1A1L3MBTL1MEN1
SCHEMBL9743389 0.76 GCGR (0.45) GCGRALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL27350569 0.74 GCGR (0.45) GCGR
SCHEMBL2648307 0.74 GCGR (0.57) GCGR
SCHEMBL2648227 0.73 GCGR (0.60) GCGRALDH1A1L3MBTL1SLC10A2
SCHEMBL2648610 0.72 GCGR (0.53) GCGRALDH1A1L3MBTL1SLC10A2HTT
SCHEMBL27311063 0.72 GCGR (0.42) GCGR
SCHEMBL2648212 0.72 GCGR (0.62) TRPM8GCGRALDH1A1L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5145857-A HMG-COA REDUCTASE-INHIBITING SUBSTITUTED AMINO-PYRIDINES BAYER AKTIENGESELLSCHAFT (DE) 1992-09-08 US disclosed