Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646446 | 0.85 | KIF11 (0.40) | GCKKMT2AMEN1 | |
| SCHEMBL2667236 | 0.84 | GCK (0.57) | GCKEPHX1KMT2AKCNH2 | |
| SCHEMBL2897166 | 0.83 | GCK (0.57) | GCKKMT2AMEN1KCNH2 | |
| SCHEMBL2648856 | 0.83 | KMT2A (0.42) | GCKKMT2AMEN1 | |
| SCHEMBL13477802 | 0.83 | GCK (0.56) | GCKEPHX1KMT2AKCNH2 | |
| SCHEMBL2648331 | 0.82 | GCK (0.36) | GCKEPHX1KMT2AMEN1 | |
| SCHEMBL6596618 | 0.81 | MEN1 (0.44) | KMT2AMEN1 | |
| SCHEMBL1107388 | 0.80 | GCK (0.58) | GCKEPHX1KMT2AMEN1KCNH2 | |
| SCHEMBL1865137 | 0.80 | GCK (0.58) | GCKEPHX1KMT2AMEN1KCNH2 | |
| SCHEMBL1865136 | 0.80 | GCK (0.58) | GCKEPHX1KMT2AMEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | claimed |
| US-6528543-B1 | Glucokinase activating for treating type II diabetes; acylurea compound, phenylacetyl-substituted; 1-(2-(3-chloro-phenyl)-3cyclopentyl-propionyl)-3-methyl-urea | HOFFMAN-LA ROCHE INC. | 2003-03-04 | — | — | US | claimed |
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6528543-B1 | Glucokinase activating for treating type II diabetes; acylurea compound, phenylacetyl-substituted; 1-(2-(3-chloro-phenyl)-3cyclopentyl-propionyl)-3-methyl-urea | HOFFMAN-LA ROCHE INC. | 2003-03-04 | — | — | US | disclosed |