Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GALK1 | P51570 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649163 | 0.86 | MAPT (0.36) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL2649161 | 0.86 | MAPT (0.36) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL2649449 | 0.85 | MAPT (0.42) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL2647828 | 0.81 | MAPT (0.46) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL8949567 | 0.78 | MAPT (0.69) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL2648334 | 0.76 | PTGER1 (0.45) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL2662913 | 0.74 | GCGR (0.65) | — | |
| SCHEMBL2648932 | 0.73 | GCGR (0.48) | MAPTALDH1A1L3MBTL1 | |
| SCHEMBL2648110 | 0.73 | LDHA (0.40) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL2648212 | 0.71 | GCGR (0.62) | MAPTALDH1A1LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |