Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649163 | 1.00 | MAPT (0.36) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2648908 | 0.88 | MAPT (0.39) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2648905 | 0.88 | MAPT (0.39) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2648375 | 0.86 | MAPT (0.43) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2650486 | 0.86 | GCGR (0.44) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2650489 | 0.86 | GCGR (0.44) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2648085 | 0.85 | LDHA (0.37) | MAPTALDH1A1LMNASMN1; SMN2APAF1 | |
| SCHEMBL2648214 | 0.82 | MAPT (0.48) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL2648215 | 0.82 | MAPT (0.48) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL2648197 | 0.81 | GCGR (0.47) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |