Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647819 | 0.83 | HCAR3 (0.53) | CNR1ALDH1A1MAPTHPGDAKR1C3 | |
| SCHEMBL2650071 | 0.82 | GAA (0.49) | GAAALDH1A1MAPTKDM4ETHRB | |
| SCHEMBL2655100 | 0.81 | GAA (0.46) | GAAALDH1A1MAPTKDM4ETHRB | |
| SCHEMBL2643439 | 0.81 | NPC1 (0.53) | CNR1GAAALDH1A1MAPTKDM4E | |
| SCHEMBL30937997 | 0.80 | MAP4K4 (0.55) | CNR1ALDH1A1KDM4ESYKNPC1 | |
| SCHEMBL17742695 | 0.80 | MAP4K4 (0.55) | CNR1ALDH1A1KDM4ESYKNPC1 | |
| SCHEMBL2645152 | 0.80 | RET (0.45) | CNR1GAAALDH1A1MAPTKDM4E | |
| SCHEMBL2647667 | 0.79 | GAA (0.48) | CNR1GAAALDH1A1MAPTKDM4E | |
| SCHEMBL7989959 | 0.79 | GAA (0.77) | GAAALDH1A1MAPTKDM4ETHRB | |
| SCHEMBL2652430 | 0.77 | AKR1C3 (0.45) | GAAALDH1A1MAPTKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821682-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA-A RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2000-07-19 | — | — | EP | disclosed |
| US-5922725-A | Benzimidazole compounds and their use as modulators of the GABAA receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| EP-0821682-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033191-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |