Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 8/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25628064 | 0.83 | CFD (0.44) | CFDCYP2D6CYP1A2CYP3A4NFKB1 | |
| SCHEMBL25632944 | 0.80 | CFD (0.45) | CFDHTR2ASLC6A4KCNH2CYP2D6 | |
| SCHEMBL17553263 | 0.80 | CFD (0.47) | CFDCYP2D6CYP1A2CYP3A4NFKB1 | |
| SCHEMBL2668988 | 0.80 | CES2 (0.41) | HTR2ASLC6A4KCNH2CYP2D6SOS1 | |
| SCHEMBL8284240 | 0.80 | CYP2D6 (0.59) | HTR2ASLC6A4KCNH2CYP2D6CYP1A2 | |
| SCHEMBL26948996 | 0.80 | CES2 (0.41) | HTR2ASLC6A4KCNH2CYP2D6SOS1 | |
| SCHEMBL2400753 | 0.79 | HTR2A (0.51) | HTR2ASLC6A4KCNH2CYP2D6CYP1A2 | |
| SCHEMBL15983857 | 0.79 | HTR2A (0.51) | HTR2ASLC6A4KCNH2CYP2D6CYP1A2 | |
| SCHEMBL15983778 | 0.79 | HTR2A (0.51) | HTR2ASLC6A4KCNH2CYP2D6CYP1A2 | |
| SCHEMBL8216990 | 0.79 | CFD (0.50) | CFDCYP2D6CYP1A2CYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023067546-A1 | NOVEL BICYCLIC HETEROARYL DERIVATIVES AS SOS1:KRAS PROTEINPROTEIN INTERACTION INHIBITORS | SATYARX PHARMA INNOVATIONS PVT LTD (IN) | 2023-04-27 | — | — | WO | disclosed |