Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648115 | 0.80 | SMN1; SMN2 (0.46) | LMNACYP3A4CYP2D6NPC1CYP2C9 | |
| SCHEMBL8218438 | 0.76 | LMNA (0.55) | LMNACYP3A4CYP2C9CYP1A2SMN1; SMN2 | |
| SCHEMBL28529318 | 0.76 | KMT2A (0.57) | LMNAKDM4EKMT2ANPSR1L3MBTL1 | |
| SCHEMBL20496442 | 0.76 | PLK1 (0.58) | LMNACYP3A4NPC1CYP1A2CYP2C19 | |
| SCHEMBL6835721 | 0.75 | KMT2A (0.53) | LMNACYP3A4CYP2D6CYP1A2KDM4E | |
| SCHEMBL28519834 | 0.74 | TDP1 (0.51) | LMNACYP2D6CYP1A2KDM4EKMT2A | |
| SCHEMBL20496487 | 0.72 | LTA4H (0.51) | LMNACYP3A4CYP2D6NPC1CYP1A2 | |
| SCHEMBL11322929 | 0.72 | KMT2A (0.55) | LMNAKDM4EKMT2AS1PR3L3MBTL1 | |
| SCHEMBL20496466 | 0.71 | LMNA (0.54) | LMNACYP3A4CYP2C9SMN1; SMN2KDM4E | |
| SCHEMBL31679680 | 0.71 | KDM4E (0.51) | CYP2D6CYP1A2SMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959886-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0959886-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5880139-A | TREATING DIABETES, OBESITY, HYPERTENSION, CACHEXIA | MERCK & CO., INC. (US) | 1999-03-09 | — | — | US | disclosed |
| WO-1998022109-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |