Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ADH1B | P00325 | 2/20 | 0.40 |
| ▸ | ADH1C | P00326 | 2/20 | 0.40 |
| ▸ | ADH1A | P07327 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ADH4 | P08319 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648892 | 1.00 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TSHREPHX2EPHX1 | |
| SCHEMBL19313250 | 0.95 | ALDH1A1 (0.60) | ALDH1A1HSD17B10TSHREPHX2EPHX1 | |
| SCHEMBL2137039 | 0.88 | EPHX2 (0.52) | ALDH1A1HSD17B10TSHREPHX2ADH1B | |
| SCHEMBL2595288 | 0.88 | EPHX2 (0.52) | ALDH1A1HSD17B10TSHREPHX2ADH1B | |
| SCHEMBL1679056 | 0.85 | ALDH1A1 (0.92) | ALDH1A1HSD17B10EPHX2EPHX1SMN1; SMN2 | |
| SCHEMBL1679059 | 0.85 | ALDH1A1 (0.92) | ALDH1A1HSD17B10EPHX2EPHX1SMN1; SMN2 | |
| SCHEMBL613478 | 0.85 | ALDH1A1 (0.92) | ALDH1A1HSD17B10EPHX2EPHX1SMN1; SMN2 | |
| SCHEMBL5909148 | 0.85 | ALDH1A1 (0.92) | ALDH1A1HSD17B10EPHX2EPHX1SMN1; SMN2 | |
| SCHEMBL5182902 | 0.83 | TSHR (0.47) | ALDH1A1HSD17B10TSHREPHX2EPHX1 | |
| Hydrochloric Acid SCHEMBL3247210 | 0.82 | ALDH1A1 (0.86) | ALDH1A1HSD17B10EPHX2EPHX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582769-B2 | Dicycloalkyl urea glucokinase activators | NOVO NORDISK A/S (DK) | 2009-09-01 | — | — | US | disclosed |
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-05-07 | — | — | US | disclosed |
| CN-101258137-A | Dicycloalkyl urea glucokinase activators | NOVO NORDISK AS (DK) | 2008-09-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | GCK, GCKR, UCK2 | ALDH1A1 3782/4885HSD17B10 1699/4885TSHR 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.