Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649835 | 0.89 | GHSR (0.35) | CHRNA4SLC6A3GHSRMAPTHTT | |
| SCHEMBL1343424 | 0.83 | GHSR (0.38) | CHRNA4SLC6A3GHSRMAPTALDH1A1 | |
| SCHEMBL1340210 | 0.80 | GAA (0.35) | MAPTRAB9ASMN1; SMN2ALDH1A1ITK | |
| SCHEMBL2650482 | 0.78 | IDH1 (0.35) | MAPTALDH1A1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL2651015 | 0.72 | CASR (0.33) | GHSRMAPTRAB9AALDH1A1 | |
| SCHEMBL1340896 | 0.71 | ALDH1A1 (0.41) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1342788 | 0.70 | MAPT (0.33) | MAPTHTTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1342409 | 0.70 | SMN1; SMN2 (0.35) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1342842 | 0.70 | GHSR (0.38) | CHRNA4SLC6A3GHSRMAPTRAB9A | |
| SCHEMBL1341777 | 0.70 | ALDH1A1 (0.40) | CHRNA4SLC6A3GHSRMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |