Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26501545 | 0.86 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2HPGDRAB9AMEN1 | |
| SCHEMBL26501695 | 0.85 | SMN1; SMN2 (0.40) | RORCALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL26501699 | 0.82 | TSHR (0.44) | ALDH1A1SMN1; SMN2HPGDRAB9AGAA | |
| SCHEMBL26501696 | 0.82 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2HPGDCYP2D6RAB9A | |
| SCHEMBL26501698 | 0.81 | TSHR (0.43) | ALDH1A1SMN1; SMN2HPGDRAB9AGAA | |
| SCHEMBL26501672 | 0.80 | PANK3 (0.43) | RORCALDH1A1DEGS1HTTKDM4E | |
| SCHEMBL26501693 | 0.78 | MAPT (0.44) | ALDH1A1SMN1; SMN2RAB9AHTTMEN1 | |
| SCHEMBL26501542 | 0.75 | ALDH1A1 (0.43) | RORCALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL26501700 | 0.74 | PTPN1 (0.40) | ALDH1A1SMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL2688260 | 0.74 | DEGS1 (0.46) | ALDH1A1DEGS1SMN1; SMN2HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321092-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321092-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | HMGCR, GCDH, CYP11A1 | RORC 2178/4885ALDH1A1 715/4885DEGS1 2553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.