Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26501545 | 0.82 | SMN1; SMN2 (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL26501796 | 0.78 | HDAC1 (0.35) | SMN1; SMN2KDM4EHDAC1HDAC6NPC1 | |
| SCHEMBL26501678 | 0.77 | PANK3 (0.42) | MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL26501699 | 0.76 | TSHR (0.44) | PTPN1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL26501542 | 0.76 | ALDH1A1 (0.43) | KMT2AALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL26501695 | 0.75 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2KDM4EMAPTNPC1 | |
| SCHEMBL26501696 | 0.75 | SMN1; SMN2 (0.39) | PTPN1WNT3AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL26501698 | 0.75 | TSHR (0.43) | PTPN1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL18291583 | 0.74 | SMN1; SMN2 (0.48) | PTPN1MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL26501697 | 0.74 | RORC (0.41) | PTPN1MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321092-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321092-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | HMGCR, GCDH, CYP11A1 | PTPN1 2829/4885WNT3A 4640/4885MEN1 2263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.