Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038816 | 0.81 | DRD2 (0.55) | AOC3ALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL10769434 | 0.79 | AOC3 (0.50) | AOC3KCNA3HDAC3HDAC4HDAC1 | |
| SCHEMBL8220198 | 0.79 | CA4 (0.44) | AOC3KCNA3LTA4HHTR1BLMNA | |
| SCHEMBL6982008 | 0.79 | AOC3 (0.50) | AOC3KCNA3HDAC3HDAC4HDAC1 | |
| SCHEMBL3729055 | 0.78 | AOC3 (0.42) | AOC3KCNA3HDAC3HDAC4HDAC1 | |
| SCHEMBL8134399 | 0.78 | KCNA3 (0.44) | AOC3KCNA3HDAC3HDAC4HDAC1 | |
| SCHEMBL1024 | 0.77 | KCNA3 (0.62) | KCNA3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6326458 | 0.77 | AOC3 (0.59) | AOC3KCNA3HDAC3HDAC4HDAC1 | |
| SCHEMBL1445312 | 0.77 | AOC3 (0.58) | AOC3KCNA3HDAC3HDAC4HDAC1 | |
| SCHEMBL419306 | 0.77 | AOC3 (0.78) | AOC3KCNA3HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294718-B1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| EP-3262026-B1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-03-18 | — | — | EP | disclosed |
| US-10428108-B2 | Difluoroketamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-9980929-B2 | Trifluoromethylpropanamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-05-29 | — | — | US | disclosed |
| EP-3294718-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2018-03-21 | — | — | EP | disclosed |
| US-20180057526-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-03-01 | — | — | US | disclosed |
| EP-3262026-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2018-01-03 | — | — | EP | disclosed |
| US-20170348257-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-12-07 | — | — | US | disclosed |
| WO-2016180751-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016135070-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-01 | — | — | WO | disclosed |
| CN-1520296-A | Amino nicotinate derivatives as glucokinase (GLK) modulators | — | 2004-08-11 | — | — | CN | disclosed |
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348257-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | PRMT7, GFRA3, PRMT5 | AOC3 3287/4885KCNA3 150/4885HDAC3 20/4885 |
| US-20180057526-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | PRMT9, CDK9, FLT3 | AOC3 4349/4885KCNA3 378/4885HDAC3 1125/4885 |
| US-10428108-B2 | Difluoroketamide derivatives | PRMT9, CDK9, FLT3 | AOC3 3970/4885KCNA3 540/4885HDAC3 1062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.