Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | FABP4 | P15090 | 3/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652010 | 0.83 | IDO1 (0.40) | IDO1FABP4FABP5NR4A2MAOA | |
| SCHEMBL2650998 | 0.77 | CFD (0.39) | IDO1FABP4FABP5 | |
| SCHEMBL10314843 | 0.73 | IDO1 (0.55) | IDO1NR4A2MAOAMAOBPNMT | |
| SCHEMBL2650913 | 0.73 | IDO1 (0.50) | IDO1NPC1RAB9ATAAR1MMP1 | |
| SCHEMBL2652478 | 0.71 | IDO1 (0.48) | IDO1MAOBNPC1RAB9ATAAR1 | |
| SCHEMBL2652142 | 0.71 | ESR1 (0.42) | IDO1MAOBTAAR1 | |
| SCHEMBL16054236 | 0.71 | TSHR (0.41) | IDO1CASP1L3MBTL1 | |
| SCHEMBL6204061 | 0.71 | TSHR (0.41) | IDO1CASP1L3MBTL1 | |
| SCHEMBL18596801 | 0.70 | IDO1 (0.52) | IDO1FABP4FABP5NR4A2MAOA | |
| SCHEMBL9503379 | 0.70 | IDO1 (0.61) | IDO1NR4A2MAOAMAOBPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |