Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652551 | 0.88 | FFAR1 (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL2652111 | 0.84 | IDO1 (0.41) | IDO1NPC1RAB9AMAOB | |
| SCHEMBL2650236 | 0.83 | IDO1 (0.48) | IDO1FABP4FABP5NR4A2NPC1 | |
| SCHEMBL2651003 | 0.83 | IDO1 (0.40) | IDO1NPC1RAB9AMAOBKMT2A | |
| SCHEMBL2652007 | 0.83 | TSHR (0.43) | MAOBL3MBTL1 | |
| SCHEMBL2650110 | 0.80 | TP53 (0.41) | MAOBKMT2AGAA | |
| SCHEMBL2651078 | 0.80 | IDO1 (0.44) | IDO1MAOAMAOBGAA | |
| SCHEMBL2650879 | 0.79 | ALDH1A1 (0.48) | MAOBKMT2A | |
| SCHEMBL2651330 | 0.77 | CYP3A4 (0.42) | IDO1NR4A2NPC1RAB9AMAOA | |
| SCHEMBL2650744 | 0.76 | MAPK14 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |