Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651003 | 0.83 | IDO1 (0.40) | IDO1ALDH1A1MAOBPARP15PARP10 | |
| SCHEMBL2651471 | 0.79 | CES2 (0.38) | IDO1ALDH1A1MAOBTDO2 | |
| SCHEMBL10314840 | 0.73 | IDO1 (0.55) | IDO1ALDH1A1MAOBPARP15PARP10 | |
| SCHEMBL2650913 | 0.73 | IDO1 (0.50) | IDO1ALDH1A1PARP10TAAR1TDO2 | |
| SCHEMBL2651416 | 0.72 | MMP2 (0.39) | IDO1MMP1MMP2MMP9MMP12 | |
| SCHEMBL2652142 | 0.71 | ESR1 (0.42) | IDO1MAOBTAAR1LMNASLC1A5 | |
| SCHEMBL2650236 | 0.71 | IDO1 (0.48) | IDO1MAOBTAAR1NPC1RAB9A | |
| SCHEMBL2650544 | 0.71 | IDO1 (0.53) | IDO1ALDH1A1MAOBKDM4E | |
| SCHEMBL6204869 | 0.71 | MEN1 (0.41) | IDO1ALDH1A1TDO2LMNAMAPT | |
| SCHEMBL2650998 | 0.70 | CFD (0.39) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |