SCHEMBL2650258

SCHEMBL2650258

COc1ccc(C=NN)c2ccccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.52
MAPT P10636 4/20 0.50
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
GCGR P47871 3/20 0.50
HPGD P15428 3/20 0.50
KDM4E B2RXH2 2/20 0.50
LMNA P02545 2/20 0.50
EP300 Q09472 1/20 0.50
KAT8 Q9H7Z6 1/20 0.50
ALDH1A1 P00352 1/20 0.50
IMPDH2 P12268 1/20 0.47
IMPDH1 P20839 1/20 0.47
POLB P06746 1/20 0.46
CHAT P28329 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
GAA P10253 1/20 0.45
CAPN1 P07384 1/20 0.44
CTSL P07711 1/20 0.44
CTSB P07858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6415092 0.84 MAPT (0.51) IDO1MAPTMEN1KMT2AGCGR
SCHEMBL2648987 0.83 IDO1 (0.45) IDO1MAPTMEN1KMT2AGCGR
SCHEMBL11287677 0.79 MEN1 (0.51) IDO1MAPTMEN1KMT2AGCGR
SCHEMBL14950340 0.77 GRIN2D (0.61) MAPTMEN1KMT2AHPGDKDM4E
SCHEMBL1665548 0.77 GRIN2D (0.61) MAPTMEN1KMT2AHPGDKDM4E
SCHEMBL31182413 0.77 GRIN2D (0.61) MAPTMEN1KMT2AHPGDKDM4E
SCHEMBL5378361 0.76 CHAT (0.53) MAPTMEN1KMT2AGCGRHPGD
SCHEMBL7239605 0.76 PLAU (0.48) MAPTMEN1KMT2AGCGRHPGD
SCHEMBL7228644 0.76 IDO1 (0.55) IDO1MAPTGCGRHPGDLMNA
SCHEMBL7230499 0.76 HPGD (0.51) MAPTMEN1KMT2AGCGRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3569248-B1 GIP INHIBITORS FOR IMPROVING COGNITIVE FUNCTION KAO CORP (JP) 2023-12-06 EP claimed
EP-3560515-B1 GIP INHIBITORS FOR USE IN IMPROVING MOTOR CONTROL FUNCTION KAO CORP (JP) 2023-11-15 EP claimed
EP-3569248-A1 COGNITIVE FUNCTION IMPROVING AGENT Kao Corporation (JP) 2019-11-20 EP claimed
US-20190330332-A1 Hypothermia Ameliorating Agent KAO CORPORATION (JP) 2019-10-31 US claimed
US-20190330333-A1 Cognitive Function Improving Agent KAO CORPORATION (JP) 2019-10-31 US claimed
US-20190330334-A1 Motor Control Function Improving Agent KAO CORPORATION (JP) 2019-10-31 US claimed
EP-3560514-A1 HYPOTHERMIA AMELIORATING AGENT Kao Corporation (JP) 2019-10-30 EP claimed
EP-3560515-A1 MOTOR CONTROL FUNCTION IMPROVING AGENT Kao Corporation (JP) 2019-10-30 EP claimed
EP-3569248-B1 GIP INHIBITORS FOR IMPROVING COGNITIVE FUNCTION KAO CORP (JP) 2023-12-06 EP disclosed
EP-3560515-B1 GIP INHIBITORS FOR USE IN IMPROVING MOTOR CONTROL FUNCTION KAO CORP (JP) 2023-11-15 EP disclosed
US-11555069-B2 Cognitive function improving agent KAO CORPORATION (JP) 2023-01-17 US disclosed
US-11319369-B2 Motor control function improving agent KAO CORPORATION (JP) 2022-05-03 US disclosed
EP-3569248-A1 COGNITIVE FUNCTION IMPROVING AGENT Kao Corporation (JP) 2019-11-20 EP disclosed
US-20190330334-A1 Motor Control Function Improving Agent KAO CORPORATION (JP) 2019-10-31 US disclosed
US-6887881-B1 Bispidine compounds useful in the treatment of cardiac arrythmias ASTRAZENECA AB (SE) 2005-05-03 US disclosed
EP-1506777-A1 OBESITY PREVENTIVE OR AMELIORATOR CONTAINING METHYLIDENE HYDRAZIDE COMPOUND AS ACTIVE INGREDIENT Sanwa Kagaku Kenkyusho Co., Ltd. (JP) 2005-02-16 EP disclosed
EP-1192154-B1 BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS ASTRAZENECA AB (SE) 2004-03-17 EP disclosed
US-6613942-B1 Nonpeptide; 4-hydroxy benzoic acid hydrazides NOVO NORDISK A/S (DK) 2003-09-02 US disclosed
EP-0994848-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2000-04-26 EP disclosed
WO-1999001423-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 1999-01-14 WO disclosed