Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.32 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20464225 | 0.89 | ALDH1A1 (0.44) | CYP2D6KCNH2HRH3HSD11B1ALDH1A1 | |
| SCHEMBL12384632 | 0.89 | CYP2D6 (0.50) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL19703906 | 0.85 | HSD11B1 (0.45) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL25034509 | 0.84 | CHRNB2 (0.35) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL14592895 | 0.84 | CYP2D6 (0.42) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL24491596 | 0.82 | CYP2D6 (0.41) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL12125541 | 0.80 | CYP2D6 (0.40) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL12384400 | 0.80 | CYP2D6 (0.40) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL15448194 | 0.79 | CYP2D6 (0.47) | CYP2D6KCNH2HRH3EPHX2HSD11B1 | |
| SCHEMBL12384517 | 0.79 | EPHX2 (0.53) | CYP2D6KCNH2HRH3EPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131535-A1 | ARYLMETHYLENE AROMATIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131535-A1 | ARYLMETHYLENE AROMATIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNJ2, KCNA3, KCNK3 | CYP2D6 670/4885KCNH2 7/4885HRH3 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.